GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs3772130 | 1 | rs17691170 | chr3:121357626 | IQCB1 | chr3:121488610-121553926:- | 0.47 | 4.32 | 3.78E-5 | Cognitive performance |
| THYM | cis | rs10935120 | 1 | rs17694011 | chr3:134213981 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.01 | 2.88E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs17694011 | chr3:134213981 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 6.04 | 2.93E-8 | Height |
| THYM | cis | rs60843830 | 1 | rs17713396 | chr2:227201 | SH3YL1 | chr2:218138-264810:- | -0.32 | -4.5 | 1.95E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs60843830 | 1 | rs17713729 | chr2:249092 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs60843830 | 1 | rs17714252 | chr2:285471 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.7E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs17761864 | 1 | rs17761723 | chr17:2107090 | SRR | chr17:2207248-2228553:+ | 0.59 | 6.45 | 4.71E-9 | Esophageal cancer (squamous cell) |
| THYM | cis | rs17761864 | 1 | rs17761864 | chr17:2171637 | SRR | chr17:2207248-2228553:+ | -0.52 | -5.52 | 2.94E-7 | Esophageal cancer (squamous cell) |
| THYM | cis | rs17761864 | 1 | rs17834627 | chr17:2198892 | SRR | chr17:2207248-2228553:+ | -0.55 | -5.52 | 2.92E-7 | Esophageal cancer (squamous cell) |
| THYM | cis | rs4409766 | 1 | rs17878846 | chr10:104630412 | SFXN2 | chr10:104474298-104498946:+ | -0.6 | -4.71 | 8.59E-6 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| THYM | cis | rs9457247 | 1 | rs1794693 | chr6:167405670 | RNASET2 | chr6:167343008-167412795:- | -0.47 | -7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs2243480 | 1 | rs1796220 | chr7:66062100 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs1796228 | chr7:66033084 | CCT6P1 | chr7:65216092-65228661:+ | 0.59 | 4.86 | 4.58E-6 | Diabetic kidney disease |
| THYM | cis | rs10935120 | 1 | rs1814336 | chr3:134200823 | ANAPC13 | chr3:134196547-134204865:- | 0.56 | 7.74 | 1.08E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs1814336 | chr3:134200823 | CEP63 | chr3:134204575-134293852:+ | 0.39 | 5.72 | 1.23E-7 | Height |